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phenobarbital will lessen the extent or impact of olanzapine/samidorphan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Powerful CYP3A4 inducers lessen amounts of olanzapine and samidorphan by~fifty% and ~75% respectively.phenobarbital will decrease the extent or influence of piroxicam by influencing